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 Features
Spring 2009 

In this issue:


Children’s National Researchers Develop Anti-Tumor Vaccine

Children’s National Medical Center, in collaboration with investigators from the University of Iowa, developed a novel anti-tumor vaccine for neuroblastoma and melanoma. The vaccine is showing significant impact on tumor growth in mice, according to new research published in the October edition of the research journal Cancer Immunology, Immunotherapy. The vaccine uses the tumor’s own protein to induce an immune system response, allowing for a personalized approach to treatment...[Read more]


Diagnosis and Treatment of Chiari Type 1 Malformations at Children’s National

Figure 1
The Division of Neurosurgery at Children’s National Medical Center evaluates hundreds of patients with Chiari malformations each year. As a leading destination in the United States for the treatment of children with this congenital defect, Children’s team has experience in determining the optimal course of treatment given each child’s unique condition.

A Chiari malformation is an anomaly involving the craniocervical junction, the area between the base of the skull and upper cervical spine. It occurs when...[Read more]


Children’s National Researchers Discover Breakthrough in Duchenne Muscular Dystrophy Study

Genetic researchers at Children’s National Medical Center and the National Center of Neurology and Psychiatry in Tokyo published the results of the first successful application of “multiple exon-skipping” to curb the devastating effects of Duchenne muscular dystrophy in an animal larger than a mouse.

Multiple exon-skipping employs multiple DNA-like molecules as a “DNA band-aids” to skip over the parts of the mutated gene that block the effective creation of proteins. The study, conducted in Japan and the United States, was published in the peer-reviewed journal of the American Neurological Association, the Annals of Neurology...[Read more]



Free Book Available

The Short Child - book offer
Children’s National is excited to offer physicians a free book, The Short Child: A Parents’ Guide to the Causes, Consequences, and Treatment of Growth Problems, written by Paul Kaplowitz, MD, chief of Endocrinology. This book will make a great addition to your medical library. Request your free copy today by e-mailing your name and mailing address to tbear@cnmc.org. A limited number of books are available.

For additional information on short stature visit, The Short Child: Referral Guidelines.
 Recently Published
The "top-down" approach to the evaluation of children with febrile urinary tract infection
Adv Urol. 2009:783409.
PMID: 19343189

Early primary repair of tetralogy of fallot
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2009:39-47.
PMID: 19349012

Image Gently: why we should talk to parents about CT in children
AJR Am J Roentgenol. 2009 May;192(5):1176-8.
PMID: 19380539

TIMP-1 Nucleates a Critical Bronchial Epithelial Response Network to Tobacco Smoke in Asthma
Proc Am Thorac Soc. 2009 May;6(3):326.
PMID: 19387048

Sports-related concussions in pediatrics
Curr Opin Pediatr. 2009 Apr 22.
PMID: 19390439

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